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However it was found in a study with rats that when acetyl-L-carnitine was provided as a supplement, the age-related decline in mitochondrial Alpha Boost activity was reversed and oxidation of fatty acids was increased. As a result of this fatty acid oxidation, even more oxidation damage to the mitochondria occurred. When a supplement of alpha lipoic acid was also given, however, the mitochondrial oxidation was reduced, so that the mitochondria produced a higher energy output with less oxidation damage.

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